Endocrine Abstracts

Introduction: Studies show that a change in lifestyle can prevent or delay progression to diabetes in those with glucose intolerance. This study aimed to survey the effects of lifestyle changes on incidents of type II diabetes in Tehran adult population.Materials and methods: This was a community based interventional study. Non-diabetic participants of Tehran Lipid and Glucose Study aged ≥20 years (6437 in control group and 2931 in intervention gro...

Objective: Although body mass index (BMI) is commonly used to assess risk for cardiovascular disease (CVD), there is an obvious need for prospective studies of different ethnics to evaluate the predicting power of various obesity variables for CVD outcomes.Methods: The study population consisted of 1931 men aged ≥40 years free of CVD at baseline. After a median follow up of 7.6 years, 254 CVD events occurred. Demographic data were collected at base...

Aims: Lifestyle modification has been shown to prevent development of Type 2 diabetes in high risk American, European and Asian populations. We wanted to test whether such intervention could have similar results in a white Middle Eastern population.Methods: A total of 8212 non-diabetic subjects≥20 years were selected by cluster random sampling method in the cross-sectional phase of the Tehran Lipid and Glucose Study (TLGS) from 1999 to 2001. A subs...

Background and aims: To compare and contrast the cardiovascular disease (CVD) risk associated with the metabolic syndrome (MetS) and dysglycemia, independent of each other, we evaluated the 6.7-year incidence risk of CVD and coronary heart disease (CHD).Methods and results: In an Iranian population, 4018 subjects ≥40 years with no history of CVD at baseline, were followed up for new CHD and CVD events. Incidence rates and hazard ratio (HR) were est...

Background: To determine the risk of cardiovascular disease (CVD) in an Iranian population according to glucose tolerance status.Methods and results: The study population consisted of 1752 men and 2273 women aged ≥40 years without CVD. After a median follow up of 7.6 years, 340 CVD events occurred (197 in men and 143 in women). Women generally had more Framingham risk score (FRS) than men (12.7 vs 11.9, P<0.001) and there was no differen...

Objective: To determine the association between markers of hepatic injury and serum, urinary, and intra-erythrocyte magnesium concentrations and dietary magnesium intake in obese children.Methods: In a case–control cross-sectional study, we studied 42 obese children and adolescents and 42 sex- and puberty-matched lean controls. Serum, urinary, and intra-erythrocyte magnesium levels, indexes of insulin sensitivity, and liver enzymes were measured. Di...